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Biotium.jpg

64601b3382479.png


艾美捷科技代理Biotium品牌全系列染料产品。

Biotium一直致力于开发和生产用于生物医学研究的荧光指示剂及其他特殊生化产品。其产品被广泛应用于细胞生 物学、蛋白质组学、分子生物学、免疫学、微生物学、诊断学、生物化学、神经科学、血液流动检测及大规模药物筛选等众多领域。产品列表如下:


产品名称货号规格
GelRed® Nucleic Acid Gel Stain 10000X in water, 0.5ml410030.5ml64601dcb19e71.png
GelRed® Nucleic Acid Gel Stain 10000X in water, 10ml41003-110ml64601dcb19e71.png
GelRed® Nucleic Acid Gel Stain 3X in water, 4L410014L64601dcb19e71.png
GelRed® Nucleic Acid Gel Stain 10000X in DMSO, 0.5ml410020.5ml64601dcb19e71.png
GelRed® Nucleic Acid Gel Stain 10000X in DMSO, 10ml41002-110ml64601dcb19e71.png
GelGreen® Nucleic Acid Gel Stain 10000X in water, 0.5ml410050.5ml64601dcb19e71.png
GelGreen® Nucleic Acid Gel Stain 10000X in water, 10ml41005-110ml64601dcb19e71.png
GelGreen® Nucleic Acid Gel Stain 10000X in DMSO, 0.5ml410040.5ml64601dcb19e71.png
GelRed® Agarose LE, 5g41029-5G5g64601dcb19e71.png
GelRed® Agarose LE, 50g41029-50G50g64601dcb19e71.png
GelGreen® Agarose LE, 5g41030-5G5g64601dcb19e71.png
GelGreen® Agarose LE, 50g41030-50G50g64601dcb19e71.png
6X GelRed® Prestain Loading Buffer with Orange Tracking Dye410101ml64601dcb19e71.png
PAGE GelRed® Nucleic Acid Gel Stain 10000X in water, 0.1ml41008-T0.1ml64601dcb19e71.png
PAGE GelRed® Nucleic Acid Gel Stain 10000X in water, 500uL41008-500uL500ul64601dcb19e71.png
PAGE GelRed® Nucleic Acid Gel Stain 1X in water, 4L410144L64601dcb19e71.png
RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 25 uL40061-T25ul64601dcb19e71.png
RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 250 uL40061250ul64601dcb19e71.png
RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 1 mL40061-11ml64601dcb19e71.png
EvaGreen® Dye, 20X in Water, 1mL31000-T1ml64601dcb19e71.png
EvaGreen® Dye, 20X in Water, 5 x 1 mL310005x1ml64601dcb19e71.png
AO Succinimidyl Ester400745mg64601dcb19e71.png
DMAO, 2 mM in DMSO400121ml64601dcb19e71.png
EB Succinimidyl Ester400725mg64601dcb19e71.png
Ethidium Homodimer III (EthD-III)400501mg64601dcb19e71.png
Ethidium Homodimer III (EthD-III), 1 mM in DMSO40051200ul64601dcb19e71.png
EvaGreen® Dye, 2000X in DMSO3101950ul64601dcb19e71.png
MB Acid400765mg64601dcb19e71.png
MB Succinimidyl Ester400755mg64601dcb19e71.png
Thiazole Green (SYBR® Green I), 10,000X in DMSO, 0.5 mL40086-0.5mL0.5ml64601dcb19e71.png
Thiazole Green (SYBR® Green I), 10,000X in DMSO, 1mL40086-1mL1ml64601dcb19e71.png
Thiazole Orange Homodimer (TOTO®-1), 1 mM in DMSO40079200ul64601dcb19e71.png
Thiazole Orange, 10 mM in DMSO400771mL64601dcb19e71.png
Thiazole Red (TO-PRO®-3), 1 mM in DMSO400871mL64601dcb19e71.png
Thiazole Red Homodimer (TOTO®-3), 1 mM in DMSO40080200ul64601dcb19e71.png
TO Succinimidyl Ester400735mg64601dcb19e71.png
DAPI, 10 mg4001110mg64601dcb19e71.png
DAPI, 10 mg (Dilactate)4000910mg64601dcb19e71.png
DAPI, 1 mL (10 mg/mL)400431ml64601dcb19e71.png
Ethidium Homodimer I (EthD-I), 1 mg400101mg64601dcb19e71.png
Ethidium Homodimer I (EthD-I), 0.5 mL (2 mM in DMSO)400140.5ml64601dcb19e71.png
GelRed® Prestain Plus 6X DNA Loading Dye410111ml64601dcb19e71.png
7-AAD, 1mg400371mg64601dcb19e71.png
7-AAD, 1 mL (1 mg/mL)400841ml64601dcb19e71.png
Acridine Orange, 10 mg/mL in Water (High Purity) (AO)4003910ml64601dcb19e71.png
Actinomycin D4003810mg64601dcb19e71.png
DiSC2(5) (High Purity)4004150mg64601dcb19e71.png
DODC (High Purity)4004050mg64601dcb19e71.png
Ethidium Bromide, 10 mg/mL in H2O4004210ml64601dcb19e71.png
Hoechst 33258, 10 mL (10 mg/mL)4004410ml64601dcb19e71.png
Hoechst 33258, 100mg40045100mg64601dcb19e71.png
Hoechst 33342, 10 mL (10 mg/mL)4004610ml64601dcb19e71.png
Hoechst 33342, 100mg40047100mg64601dcb19e71.png
PMAxx™ Dye, 20 mM in H2O40069100ul64601dcb19e71.png
Propidium Iodide (PI), 10 mL (1 mg/mL in Water)4001710ml64601dcb19e71.png
Propidium Iodide (PI), 2 mL (50 ug/mL in Buffer)400482ml64601dcb19e71.png
Propidium Iodide (PI), 100 mg40016100mg64601dcb19e71.png
PMA (Propidium Monoazide), 100uL40019100ul64601dcb19e71.png
PMA (Propidium Monoazide), 1mg400131mg64601dcb19e71.png
Ethidium Monoazide Bromide (EMA)400151mg64601dcb19e71.png
< " data-original="http://pharna.51antibodies.com/template/company/xys_lvse/skin/image/lazyLoad.jpg" alt="Biotium全系列染料,热门产品现货">
Biotium全系列染料,热门产品现货
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Premetek.jpg

Premetek公司致力于为学术客户和工业客户提供化学试剂、纳米材料和催化剂,同时也提供多领域的研发服务。通过不断地与业内专业企业进行技术整合,Premetek不断更新产品,并为材料科学和催化领域提供了最多样化和可扩展的选择。

Our retail objectives are to offer the most expansive selection of premium products, provide easy and friendly service, offer the fastest delivery time possible, and ensure that every customer is satisfied with their purchase. Our inventory is determined by extensive market research, attendance at international tradeshows and conferences, customer feedback, and working closely with industry experts and vendors. Premetek is committed to continually improving our services and being the premier online market place for all your needs.

Premetek公司的主要产品包括:

Nanomaterials

Nanomaterial Suspension

Pt,Pd Catalysts -Hydrogenation

Pt,Pd Catalysts -Red/Oxidation

Pt Catalysts - Electrochemistry

Pt Alloy Catalysts - Electrochemistry

Pd Alloy Catalysts - Electrochemistry

Pd,Ru,Ir,Rh,Au Catalysts - Electrochemistry

Fe,Co,Ni,Cu,Ag Catalysts - Electrochemistry

Pt,Pd,Ru,Ir,Rh,Au-Organometallics

Pt, Pd, Rh Homogeneous Catalysts

Custom Products

Special catalysts in stock


品名货号规格
Aluminum titanate, Al2TiO5, 40 g eachN10A100040g
Barium strontium titanium oxide, BaSrTi2O6, 40 g eachN10B200040g
Calcium titanate, CaTiO3, 40 g eachN10C100040g
Calcium zirconium titanium oxide, CaZrTi2O3, 40 g eachN10C200040g
Cadmium tungsten oxide, CdWO4, 40 g eachN10C300040g
Cerium aluminate, CeAlO3, 40 g eachN10C400040g
Copper aluminate, CuAl2O4, 40 g eachN10C500040g
Iron nickel oxide, FeNiO4, 40 g eachN10I100040g
Lanthanum chromite, LaCrO3, 40 g eachN10L100040g
Lanthanum manganite , LaMnO3, 40 g eachN10L300040g
Lanthanum substituted lithium titanate, (LaLi3)TiO3, 40 g eachN10L500040g
Lead zirconium substituted titanate, PbZr0.2Ti0.8O3, 40 g eachN10L600040g
Manganese titanate, MnTiO3, 40 g eachN10M100040g
Magnesium aluminate, MgAl2O4, 40 g eachN10M200040g
Nickel cobalt oxide, NiCoO2, 40 g eachN10N100040g
Strontium bismuth niobium oxide, SrBi2Nb2O9, 50 g eachN10S100040g
Strontium ferrite, SrFe12O19, 40 g eachN10S200040g
Yttrium aluminum oxide,  Y3Al5O12, 40 g eachN10Y100040g
Yttrium iron oxide, Y3Fe5O12, 40 g eachN10Y200040g
Zinc iron oxide, ZnFe2O4, 40 g eachN10Z100040g
Zinc titanium oxide, ZnTiO3, 40 g eachN10Z200040g
Concentrated Suspension of Nanoscaled Titanium Dioxide (TiO2), 5 kgN-10005kg
Concentrated Suspension of Nanoscaled Zinc Oxide (ZnO), 5 kgN-20005kg
Concentrated Suspension of Nanoscaled Zinc Oxide (ZnO), 5 kgN-20105kg
Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-30005kg
Concentrated Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-30105kg
Concentrated Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-30205kg
Concentrated Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-31305kg
Concentrated Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-32205kg
Concentrated Suspension of Nanoscaled Iron Oxide (Fe2O3), 5 kgN-32305kg
0.1% Pt on activated carbon powder, 10 g eachP10J100110g
0.5% Pt on activated carbon powder, 10 g eachP10J100510g
1.0% Pt on activated carbon powder, 10 g eachP10J101010g
5.0% Pt on activated carbon powder, 10 g eachP10J105010g
10% Pt on activated carbon powder, 10 g eachP10J110010g
20% Pt on activated carbon powder, 10 g eachP10J120010g
0.1% Pt on granular carbon, 10 g eachP10J200110g
0.5% Pt on granular carbon, 10 g eachP10J200510g
1.0% Pt on granular carbon, 10 g eachP10J201010g
5.0% Pt on granular carbon, 10 g eachP10J205010g
0.1% Pd on activated carbon powder, 10 g eachP30J100110g
0.5% Pd on activated carbon powder, 10 g eachP30J100510g
1.0% Pd on activated carbon powder, 10 g eachP30J101010g
5.0% Pd on activated carbon powder, 10 g eachP30J105010g
10% Pd on activated carbon powder, 10 g eachP30J110010g
20% Pd on activated carbon powder, 10 g eachP30J120010g
0.1% Pd on granular carbon, 10 g eachP30J200110g
0.3% Pd on granular carbon, 10 g eachP30J200310g
0.5% Pd on granular carbon, 10 g eachP30J200510g
1.0% Pd on granular carbon, 10 g eachP30J201010g
5.0% Pd on granular carbon, 10 g eachP30J205010g
0.5% Pd on alumina spheres, 3 mm, SA=P30L100510g
1.0% Pd on alumina spheres, 3 mm, SA=P30L101010g
0.1% Pt on alumina powder, 10 g eachP10K100110g
0.5% Pt on alumina powder, 10 g eachP10K100510g
1.0% Pt on alumina powder, 10 g eachP10K101010g
5.0% Pt on alumina powder, 10 g eachP10K105010g
10% Pt on alumina powder, 10 g eachP10K110010g
20% Pt on alumina powder, 10 g eachP10K120010g
0.1% Pd on alumina powder, 10 g eachP30K100110g
0.5% Pd on alumina powder, 10 g eachP30K100510g
1.0% Pd on alumina powder, 10 g eachP30K101010g
5.0% Pd on alumina powder, 10 g eachP30K105010g
10% Pd on alumina powder, 10 g eachP30K110010g
20% Pd on alumina powder, 10 g eachP30K120010g
5% Pt on Vulcan XC-72P10A0501g/5g
10% Pt on Vulcan XC-72P10A1001g/5g
20% Pt on Vulcan XC-72P10A2001g/5g
30% Pt on Vulcan XC-72P10A3001g/5g
40% Pt on Vulcan XC-72P10A4001g/5g
50% Pt on Vulcan XC-72P10A5001g/5g
60% Pt on Vulcan XC-72P10A6001g/5g
80% Pt on Vulcan XC-72P10A8001g/5g
Pt Black, High surface area: 40-50 m2/g, Low density: 0.6-0.9 g/mlP10V0101g/5g
20% Pt on Durable CarbonP10D2001g/5g
20% Pt on Vulcan XC-72RP10B2001g/5g
40% Pt on Vulcan XC-72RP10B4001g/5g
60% Pt on Vulcan XC-72RP10B6001g/5g
40% Pt on high surface area KetjenblackP10E4001g/5g
50% Pt on high surface area Ketjenblack,P10E5001g/5g
60% Pt on high surface area KetjenblackP10E6001g/5g
70% Pt on high surface area KetjenblackP10E7001g/5g
5% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A0501g/5g
10% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A1001g/5g
20% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A2001g/5g
30% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A3001g/5g
40% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A4001g/5g
50% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A5001g/5g
60% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72RP12B6001g/5g
60% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A6001g/5g
80% Pt-Ru (1:1 atomic ratio) on Vulcan XC-72P12A8001g/5g
Pt-Ru Black (1:1 atomic ratio)P12V0101g/5g
Pt-Ru Black (2.5:1 atomic ratio)P12V2501g/5g
Pt-Ru-Ir Black (1:1:1 atomic ratio)P124V0101g/5g
50% Pt-Ru (1:1 atomic ratio) on KetjenblackP12E5001g/5g
60% Pt-Ru (1:1 atomic ratio) on KetjenblackP12E6001g/5g
75% Pt-Ru (1:1 atomic ratio) on KetjenblackP12E7501g/5g
20% Pt-Pd (1:3 atomic ratio) on Vulcan XC-72P13A2031g/5g
20% Pt-Pd (1:1 atomic ratio) on Vulcan XC-72P13A2001g/5g
20% Pt-Pd (3:1 atomic ratio) on Vulcan XC-72P13A2301g/5g
40% Pt-Pd (1:1 atomic ratio) on Vulcan XC-72P13A4001g/5g
Pt-Pd Black (1:1 atomic ratio)P13V0101g/5g
Pt-Rh Black (1:1 atomic ratio)P15V0101g/5g
20% Pt-Ir (1:3 atomic ratio) on Vulcan XC-72P14A2031g/5g
20% Pt-Ir  (1:1 atomic ratio) on Vulcan XC-72P14A2001g/5g
20% Pt-Ir (3:1 atomic ratio) on Vulcan XC-72P14A2301g/5g
40% Pt-Ir (1:1 atomic ratio) on Vulcan XC-72P14A4001g/5g
Pt-Ir Black (1:1 atomic ratio)P14V0101g/5g
20% Pt-Cr (3:1 atomic ratio) on Vulcan XC-72P1AA2301g/5g
40% Pt-Cr (3:1 atomic ratio) on Vulcan XC-72P1AA4301g/5g
20% Pt-Fe (1:1 atomic ratio) on Vulcan XC-72P1BA2001g/5g
40% Pt-Fe (1:1 atomic ratio) on Vulcan XC-72P1BA4001g/5g
40% Pt-Fe (3:1 atomic ratio) on Vulcan XC-72P1BA4301g/5g
20% Pt-Co (1:1 atomic ratio) on Vulcan XC-72P1CA2001g/5g
20% Pt-Co (3:1 atomic ratio) on Vulcan XC-72P1CA2301g/5g
40% Pt-Co (1:1 atomic ratio) on Vulcan XC-72P1CA4001g/5g
40% Pt-Co (3:1 atomic ratio) on Vulcan XC-72P1CA4301g/5g
60% Pt-Co (3:1 atomic ratio) on KetjenblackP1CE6301g/5g
20% Pt-Ni (1:1 atomic ratio) on Vulcan XC-72P1DA2001g/5g
20% Pt-Ni (3:1 atomic ratio) on Vulcan XC-72P1DA2301g/5g
40% Pt-Ni (1:1 atomic ratio) on Vulcan XC-72P1DA4001g/5g
40% Pt-Ni (3:1 atomic ratio) on Vulcan XC-72P1DA4301g/5g
60% Pt-Ni (3:1 atomic ratio) on KetjenblackP1DE6301g/5g
20% Pt-Cu (1:1 atomic ratio) on Vulcan XC-72P1EA2001g/5g
20% Pt-Cu (3:1 atomic ratio) on Vulcan XC-72P1EA2301g/5g
20% Pt-Sn (3:1 atomic ratio) on Vulcan XC-72P1FA2301g/5g
40% Pt-Sn (3:1 atomic ratio) on Vulcan XC-72P1FA4301g/5g
20% Pd-Ir (1:3 atomic ratio) on Vulcan XC-72P34A2031g/5g
20% Pd-Ir (1:1 atomic ratio) on Vulcan XC-72P34A2001g/5g
20% Pd-Ir (3:1 atomic ratio) on Vulcan XC-72P34A2301g/5g
20% Pd-Rh (1:1 atomic ratio) on Vulcan XC-72P35A2001g/5g
20% Pd-Rh (3:1 atomic ratio) on Vulcan XC-72P35A2301g/5g
20% Pd-Ni (1:1 atomic ratio) on Vulcan XC-72P3DA2001g/5g
40% Pd-Au (1:1 atomic ratio) on KetjenblackP13E4001g/5g
5% Pd on Vulcan XC-72P30A0501g/5g
10% Pd on Vulcan XC-72P30A1001g/5g
20% Pd on Vulcan XC-72P30A2001g/5g
40% Pd on Vulcan XC-72P30A4001g/5g
40% Pd on KetjenblackP30E4001g/5g
60% Pd on Vulcan XC-72P30A6001g/5g
80% Pd on Vulcan XC-72P30A8001g/5g
Pd Black, High surface area 40~48 m2/gP30V0101g/5g
20% Ru on Vulcan XC-72P20A2001g/5g
40% Ru on Vulcan XC-72,P20A4001g/5g
Ru Black, High surface area 38~48 m2/gP20V0101g/5g
RuO2 powder, Surface area 18-25 m2/gP20V0201g/5g
5% Ir on Vulcan XC-72P40A0501g/5g
10% Ir on Vulcan XC-72P40A1001g/5g
20% Ir on Vulcan XC-72P40A2001g/5g
40% Ir on Vulcan XC-72P40A4001g/5g
Ir Black, High Surface area, 55~65 m2/g,P40V0101g/5g
IrOx powder, conductive, SA:10-20 m2/gP40V0201g/5g
Ru-Ir Black (1:1 atomic ratio)P24V0101g/5g
20% Rh on Vulcan XC-72P50A2001g/5g
Rh Black, High surface area 40~50 m2/gP50V0101g/5g
20% Au on Vulcan XC-72 (Au particle size: 4-8 nm)P60N2001g/5g
20% Au on Vulcan XC-72 (Au particle size: ~25 nm)P60A2001g/5g
30% Au on Vulcan XC-72 (Au particle size: 8 nm)P60N3001g/5g
40% Au on Vulcan XC-72 (Au particle size: ~35 nm)P60A4001g/5g
40% Au on Ketjenblack (Au particle size: 4 nm)P60E4001g/5g
60% Au on Vulcan XC-72 (Au particle size: ~45 nm)P60A6001g/5g
5% Fe on Vulcan XC-72T10A0501g/5g
10% Fe on Vulcan XC-72T10A1001g/5g
20% Fe on Vulcan XC-72T10A2001g/5g
1% Co on Vulcan XC-72T20A0101g/5g
5% Co on Vulcan XC-72T20A0501g/5g
10% Co on Vulcan XC-72T20A1001g/5g
20% Co on Vulcan XC-72T20A2001g/5g
1% Ni on Vulcan XC-72T30A0101g/5g
5% Ni on Vulcan XC-72T30A0501g/5g
10% Ni on Vulcan XC-72T30A1001g/5g
20% Ni on Vulcan XC-72T30A2001g/5g
40% Ni on Vulcan XC-72T30A4001g/5g
1% Cu on Vulcan XC-72T40A0101g/5g
5% Cu on Vulcan XC-72T40A0501g/5g
10% Cu on Vulcan XC-72T40A1001g/5g
20% Cu on Vulcan XC-72T40A2001g/5g
40% Cu on Vulcan XC-72T40A4001g/5g
60% Cu on Vulcan XC-72T40A6001g/5g
20% Ag on Vulcan XC-72P70A2001g/5g
40% Ag on Vulcan XC-72P70A4001g/5g
60% Ag on Vulcan XC-72P70A6001g/5g
80% Ag on Vulcan XC-72P70A8001g/5g
Platinum (II)  acetylacetonate, 5 g eachP10H1105g
(1,5-Cyclooctadiene)dimethylplatinum(II), 1 g eachP10H1201g
Dichloro(1,5-cyclooctadiene)platinum(II), 5 g eachP10H1305g
Diphenyl(1,5-cyclooctadiene)platinum(II), 5 g eachP10H1405g
Trimethylbenzylammoniumhexachloroplatinate (IV), 1 g eachP10H1501g
Palladium(II) acetylacetonate, 5 g eachP30H1105g
Dichloro(1,5-cyclooctadiene)palladium(II), 5 g eachP30H1205g
Hermann's Catalyst, 5 g eachP30H1305g
1,1'-Bis(di-tert-butylphosphino)ferrocene palladium dichloride, 1 g eachP30H1401g
Bis(dibenzylideneacetone)palladium(0), 5 g eachP30H1505g
Palladium(0) tetrakis(triphenylphosphine), 5 g eachP30H1605g
Ruthenium(III) acetylacetonate, 5 g eachP20H1105g
Dichloro(1,5-cyclooctadiene)ruthenium(II), polymer, 5 g eachP20H1205g
Bis(cyclopentadienyl)ruthenium, 5 g eachP20H1305g
Irridium(III) acetylacetonate, 5 g eachP40H1105g
Chloro(1,5-cyclooctadiene)iridium(I) dimer, 5 g eachP40H1205g
Rhodium(III) acetylacetonate, 5 g eachP50H1105g
Chloro(1,5-cyclooctadiene)rhodium(I) dimer, 1 g eachP50H1201g
Chloro(triphenylphosphine)gold(I), 5 g eachnewitem35g
Bromo(triphenylphosphine)gold(I), 5 g eachP60H1105g
Chloro(1,5-cyclooctadiene)rhodium(I) dimer, 98% 1 gP50-0021g
Chloro(1,5-cyclooctadiene)rhodium(I) dimer, 98% 1 gP50-0021g
Doyledirhodium catalyst-Rh2(5R-MPPIM)4, 1 gP50-0011g
Doyledirhodium catalyst-Rh2(5S-MPPIM)4, 1 gP50-0031g


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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com


" data-original="http://pharna.51antibodies.com/template/company/xys_lvse/skin/image/lazyLoad.jpg" alt="Premetek">
Premetek
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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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